DUT MaxPab mouse polyclonal antibody (B01)
产品名称： DUT MaxPab mouse polyclonal antibody (B01)
英文名称： DUT MaxPab mouse polyclonal antibody (B01)
产品编号： H00001854-B01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human DUT protein.
- Immunogen:
- DUT (NP_001020419, 1 a.a. ~ 252 a.a) full-length human protein.
- Sequence:
- MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- No additive
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- Note:
- For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of DUT expression in transfected 293T cell line (H00001854-T01) by DUT MaxPab polyclonal antibody.
Lane 1: DUT transfected lysate(27.72 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 1854
- GeneBank Accession#:
- NM_001025248
- Protein Accession#:
- NP_001020419
- Gene Name:
- DUT
- Gene Alias:
- FLJ20622,dUTPase
- Gene Description:
- deoxyuridine triphosphatase
- Omim ID:
- 601266
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq
- Other Designations:
- dUTP nucleotidohydrolase,dUTP pyrophosphatase,deoxyuridine 5'-triphosphate nucleotidohydrolase
- Gene Pathway
- Related Disease